Type 2 Diabetes Mellitus (T2DM) is an epidemic and alarming metabolic disorder. The Centers for Disease Control and Prevention (CDC) estimated that in 2005 the prevalence of diabetes in the United States was 20.8 million. Diabetes is diagnosed in 14.6 million persons and undiagnosed in 6.2 million. T2DM is 90% to 95% of prevalent diabetes. About 41 million people in the United States are believed to have pre-diabetes. The main etiologic pathways of T2DM are insulin resistance and lack of compensatory insulin secretion.