Cancer pill prolongs colon cancer survival in early clinical trial

Though the study was a Phase II clinical trial, the medicine KRX-0401 appeared to have success in a tough segment of oncology: metastatic colon cancer.

We haven't had a new drug in colon cancer since Erbitux and Vectibix in 2006. Keryx appears poised to open a Phase III clinical trial, and positive movement on their share price today means they'll probably have the dough to do it (otherwise get bought).

It's pretty rare for a phase II clinical trial to have positive survival results. Either this drug is poised to become the next blockbuster, or it's the flash in the pan of the week.

Lipoprotein (a) and coronary disease

This interesting article in NEJM was ignored by the press, probably because it's complex and also because it came out right at Christmas.

Lipoprotein (a) has been around for many years as a coronary risk factor, only problem is we don't have treatments that modify it.

The new paper shows that coronary risk is correlated with blood levels of lipoprotein (a) and these are correlated with genetic variants in inherited DNA.

Eric Topol reviewed this on his blog:


#Get a particular RSS feed and access the titles for further analysis use XML::RSS; use LWP::Simple; # Declare variables my $content; my $file; # MAIN # check for command-line argument die "Usage: ( | )\n" unless @ARGV == 1; # get the command-line argument my $arg = shift; # create new instance of XML::RSS my $rss = new XML::RSS; # argument is a URL if ($arg=~ /http:/i) { $content = get($arg); die "Could not retrieve $arg" unless $content; # parse the RSS content $rss->parse($content); # print the title and link of each RSS item foreach my $item (@{$rss->{'items'}

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