A big part of the problem in medicine is the lack of good targeting technology.  This thought occurred to me as I was lamenting how slowly my steroids were reversing an autoimmune hemolytic anemia today.  If only I could target the exact antibody that was consuming the red cells! Was the antibody directed against a red cell membrane protein or a lipid component?  I have no way of finding that out clinically let alone selecting that bad antibody for destruction.  As I explained to the patient the immune system's making too much of the bad antibody and not enough of the good antibodies.