Previously only reported with high-dose IV bisphosphonates for metastatic cancer looks like the oral bisphosphonates are also associated with jaw osteonecrosis (bone death). http://www.sciencedaily.com/releases/2009/01/090101135207.htm These drugs are commonly used for osteoporosis. The study comes from the USC School of Dentistry giving that school something more than just a bowl win to be proud of.

Patients who take bisphosphonates for osteoporosis could face higher risks of serious atrial fibrillation (AF) or irregular heartbeats claim a new study. The study presented at the 74th annual international scientific assembly of the American College of Chest Physicians (ACCP) or “CHEST 2008” shows that people using alendronate or zoledronic acid two common medications to slow or prevent the development of osteoporosis had significantly greater chances of encountering serious AF including hospitalization or death when compared with placebo.

Exciting: Gene for bisphosphonate jaw osteonecrosis in cancer patients discovered