FDAPhase

7-29-11 abstracts (only 3!)

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19: Low-dose diethylstilbestrol for the treatment of advanced prostate cancer.
Urol Oncol. 2011 Jul 25; [Epub ahead of print]

Interesting PubMed items 8/4/10

An occasional ongoing series of my results as I train my classifier.  I have over 400 abstracts in the training set, and I still get dreck sometimes.  Hope this is of some assistance to someone....

1: PMID 20677480 Endometrial ablation with paracervical block.

2: PMID J Reprod Med. 2009 Oct;54(10):639-44. Breast mass in a patient with ovarian cancer: a case report.

Novel Hsp90 Inhibitor to Begin Phase 1 Study in Cancer Patients

Salt Lake City April 8 2009 -- Myriad Pharmaceuticals Inc. announced today that the FDA has approved an Investigational New Drug (IND) application to begin a Phase 1 clinical study with its Hsp90 inhibitor MPC-3100 for the treatment of cancer. The clinical development plan for MPC-3100 is designed to expedite the drug candidate through the clinical development path. The Phase 1 trial will assess the safety and pharmacokinetics profile of MPC-3100.

Gleevec gets post-op prevention indication for GIST

Gastrointestinal stromal tumor (GIST) is a critical cancer of the gastrointestinal tract. It is also known as soft tissue sarcomas. The prevalence of GIST is likely to be 4 500 - 6 000 new cases per year in the US. Surgery is the normal treatment of local GIST. GIST tumors more often recurs in as many as one of two patients after its initial removal. Repeated GISTs are frequently more persistent than primary tumors with relapses related with lower survival rates. Gleevec is the lone treatment recognized to delay the recurrence of this aggressive cancer.

First gout drug in forty years nears approval

Gout is a painful condition that occurs when the bodily waste product of uric acid precipitates as needle-like crystals in the joints and/or soft tissues. In the joints these crystals cause inflammatory arthritis which results in sporadic swelling redness heat and pain in the joints. In many people gout mainly affects the joints of the big toe a condition known as podagra.  Many other joints and areas around the joints like the insteps ankles heels knees wrists fingers and elbows can also be affected. Uric acid crystals can also form in the kidneys and results in kidney stones.

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